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FAN
GmbH - Research Institute for Applied Neurosciences
was founded in 1996 in order to serve the increasing demand of target
identification and drug screening. FAN is an European preclinical and
clinical contract research organization. It focuses on central nervous system
drug target discovery, especially in the fields of stroke, Alzheimer's disease
and brain stem cells. FAN and its local partners of the Magdeburg neuroscience centre assist
pharmaceutical and biotech companies in selecting appropriate and modern test
models.
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This
company's internationally renowned expertise in the fields of neuroplasticity,
neuroprotection, and neurorepair is offered to life science companies to set up
faster and more flexible discovery programmes for future markets. Costumers can
choose from a wide range of individual services, including long-term cooperation
in R&D projects. FAN GmbH maintains the very highest
standards throughout every stage of a study, from initial advice as to
which tests are required, through study design and conduct to the
production of final reports. Our services are offered under several
flexible arrangements. Direct contact between sponsors and FAN GmbH project co-ordinators
ensures fast exchange of information. FAN GmbH recognises the central
importance of confidentiality and reliability.
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FAN
GmbH has developed, optimised and standardised
several in vitro and in vivo approaches, e.g.:
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Endothelin-induced
focal ischemia |
| Immunohistochemical
characterization of brain stem cell proliferation |
| Long-term
recordings of LTP and LTD |
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Mice
phenotyping (electrophysiology & learning)
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FAN
offers you expert-based contract research and consulting in preclinical Neuropharmacology and Neurodiagnostics. FAN increases your laboratory capacity
by providing the following measuring techniques and screening methods for the
preclinical development of neuropharmaceuticals as e.g. neuroprotective drugs,
nootropics, and neurotrophines:
| Rodent models of
human diseases |
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Focal and
global ischemia models (2VO/4VO, MCAO) |
| Electrophysiology
of long-term potentiation (LTP) in vitro und in vivo |
| Proliferation
and neurogenesis assays in vivo and in slice cultures |
| Electrophysiology
and death staining in organotypic brain slice cultures |
| Stereotaxic
techniques |
| Drug
delivery (IV, SC, IP, ICV) |
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Learning
and memory models |
| Sensorimotor
behavioural tests |
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Confocal
laserscan microscopy |
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Protein
expression at mRNA- and protein level |
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Immunohistochemistry
& stem cell proliferation (BrdU) |
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Cytotoxicity
tests in vitro |
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Clinical
trials, functional magnet resonance imaging (fMRI) |
| Mitochondrial
function tests |
| Antidepressiva
and neuroleptica tests |
| Stem Cell Assay in
organotypic brain slices |
For
details please check Our
Services!
Our
specific expertise:
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Stroke
mechanisms & neurotrauma |
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Synaptic
plasticity, LTP, learning and memory |
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Regenerative
processes, immunophillins, neurotrophins |
| Glutamate
receptors, protease-activated receptors, ion exchangers |
| Phenotypic
characterization of transgenic mice |
| Neuroimmunology
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